No, Michael Urie and Brendon Urie are not brothers. They have different family backgrounds. 

The actor was born in Huston, Texas, Southern United States. However, he later grew up in Collin County Plano. He belongs to a mixed ethnic background of Scottish and Italian descent parents, as he mentioned on the talk show Late Night with Conan O'Brien. 

Talking tabout the Panic! at the Disco lead vocalist, he was born in St. George, Utah, United States. When he was only 2, his family moved to Las Vegas, Nevada. 

Like The Decoy Bride star, they both are from mixed ethnic groups. The singer's mother, Grace Urie, is of Polynesian descent from Hawaii. As a result, he is a quarter Polynesian.

The musician was raised in a Mormon Church family, with faith in Jesus. At 17, he left the LDS group as he felt displeasure and didn't believe in the church's ideology.

The Single All the Way star completed his graduation from Plano Senior High School and later joined Colin County Community College. Besides, he moved to New York City when he got accepted to Juilliard School and graduated in 2003. 

Meanwhile, the guitarist joined the Palo Verde High School, where he became part of a guitar class and friends with Panic bassist Brent Wilson. However, he completed his high school studies in 2005.

Talking about their married life, the singer married Sarah Orzechowski in 2013, and the couple is expecting a baby. In the case of the actor, he is in a relationship with The Bite star Ryan Spahn for the long term. 

Fans said Michael and Brendon Urie not being related still blows their mind. Some even thought they were the same person.

Michael has only one sibling, Laura Urie. As a result, both the musician and the actor are the youngest son in their family.

Laura is the elder sister of the actor. She was born in Huston, Texas, and grew up with her brother in Plano, Texas. She is of half-Scottish and half-Italian ancestry.

The native Texan actor conveyed his sister's childhood picture on sibling day on April 11, 2015. They were enjoying the time in a boat.

He captioned, 'Happy siblings day (belated) to awesome sis Laura.' He jokes and says she was incredible in their teenage.

Brendon is the youngest son of Grace and Boyd Urie. He grew up with four siblings, Matthew Allred, Mason, Kyla, and Kara Urie. 

Matthew Allred, aka Matt, is the eldest child in his family and is the financial advisor and Franchise Owner at Ameriprise Financial Services, Inc. He is nine years older than the songwriter. He has already married and had kids with his partner. 

Mason is also the elder brother of the singer, as he is six years older than him. He is the media assistant professor at the faculty of Arts & Letters. His journal has been published in journals, including Film History and Mormon Studies Review.

Kyle is the 38-year-old sister of the musician. She married Christensen and has four children. She recently lived with her family in Las Vegas, Nevada. 

Kara is a third-generation therapist, as her father and grandfather were members of the marriage and Family Therapy practice. She tied the knot with Benjamin Lott.